Differences in fatigue-like behavior in the lipopolysaccharide and poly I:C inflammatory animal models

Central fatigue is a condition associated with impairment of the central nervous system often leading to manifestation range debilitating symptoms. Fatigue can be consequence systemic inflammation following an infection. Administration lipopolysaccharide (LPS) and polyriboinosinic:polyribocytidlic (poly I:C) animals induce by mimicking bacterial or viral infection respectively therefore have been used as models fatigue. We evaluated phenotypic behaviors exhibited in LPS poly I:C animal assess whether they adequately replicate symptomology humans. In addition standard observation- intervention-based behavioral assessments, we powerful in-cage monitoring technology quantify rodent behavior without external interference. treated Sprague Dawley rats displayed ‘sickness behaviors’ elevated temperature, weight loss reduced activity open field test within 24 h post-treatment, but only LPS-treated these beyond acute timepoints. Once sickness diminished, increase reward-seeking motivation behaviors. Overall, results suggest that model produces extensive sustained fatigue-like phenotype, whereas produced effects. Our more suitable candidate for further studies on behavior.